abstract：OBJECTIVE:Associations of glycated hemoglobin A1c (HbA1c) levels to incident coronary and cardiovascular events among non-diabetic patients with coronary artery disease are unclear. We investigated relations of HbA1c to long-term prognosis in such patients. METHODS:A prospective cohort of 2519 patients undergoing elec...

journal_title：Atherosclerosis

authors： Rebnord EW,Pedersen ER,Strand E,Svingen GF,Meyer K,Schartum-Hansen H,Løland KH,Seifert R,Ueland PM,Nilsen DW,Nordrehaug JE,Nygård O

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:Recent data suggest the involvement of dectin-1 in atherosclerosis through regulation of local reactive oxygen species production. The aim of the current study was to assess the effect of dectin-1 deficiency on atherosclerotic plaque development. METHODS:Using immunohistochemistry dectin-1 expression was obs...

journal_title：Atherosclerosis

authors： Szilagyi K,Gijbels MJ,van der Velden S,Heinsbroek SE,Kraal G,de Winther MP,van den Berg TK

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:To determine the association of circulating P-selectin with prevalent and incident peripheral artery disease (PAD), the ankle brachial index (ABI), and change in the ABI. METHODS:The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective population-based cohort study including 6814 European descent, A...

journal_title：Atherosclerosis

authors： Wassel CL,Berardi C,Pankow JS,Larson NB,Decker PA,Hanson NQ,Tsai MY,Criqui MH,Allison MA,Bielinski SJ

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The EPA/AA ratio has emerged as a predictor of mortality endpoints in cardiac disease; however, its prognostic value in peripheral artery disease (PAD) patients is unclear. We assessed the serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio in patients with PAD caused by femoropopliteal artery l...

journal_title：Atherosclerosis

authors： Hishikari K,Kimura S,Yamakami Y,Kojima K,Sagawa Y,Otani H,Sugiyama T,Kuwahara T,Hikita H,Takahashi A,Isobe M

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:The association of high-density lipoprotein particle (HDL-P) with atherosclerosis may be stronger than that of HDL-cholesterol (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of coronary heart disease (CHD) remains unclear. This stud...

journal_title：Atherosclerosis

authors： Zaid M,Fujiyoshi A,Miura K,Abbott RD,Okamura T,Takashima N,Torii S,Saito Y,Hisamatsu T,Miyagawa N,Ohkubo T,Kadota A,Sekikawa A,Maegawa H,Nakamura Y,Mitsunami K,Ueshima H,SESSA Research group.

更新日期：2015-04-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and the incidence of which is rising rapidly due to the increasing epidemic of obesity in both adults and children. The initial accumulation of fat followed by subsequent inflammation is central to the development of liver...

journal_title：Atherosclerosis

authors： Than NN,Newsome PN

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:The cluster of differentiation-1d (CD1d) recognizes and presents the lipid antigens to NK-T lymphocytes. Atherosclerotic lesions contain atherogenic lipids, mainly cholesterol and its oxides. Peroxisome proliferator-activated receptor-γ (PPARγ) is also known to exist in atherosclerotic lesions, participating ...

journal_title：Atherosclerosis

authors： Rosales C,Tang D,Geng YJ

更新日期：2015-03-01 00:00:00

abstract：:Coronary artery calcium (CAC) scanning is a reliable, noninvasive technique for estimating overall coronary plaque burden and for identifying risk for future cardiac events. Arthur Agatston and Warren Janowitz published the first technique for scoring CAC scans in 1990. Given the lack of available data correlating CAC...

journal_title：Atherosclerosis

authors： Alluri K,Joshi PH,Henry TS,Blumenthal RS,Nasir K,Blaha MJ

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To investigate cross-sectional and longitudinal associations between serum total bilirubin (TB) and dyslipidemia. METHODS:Odds ratios (ORs) of prevalent dyslipidemia for TB were calculated in 2113 men and 1265 women. Correlation coefficients between baseline TB as well as the change in TB over 5 years and ba...

journal_title：Atherosclerosis

authors： Oda E

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:Proprotein convertase subtilisin/kexin type 9 (PCSK9) is highly expressed in the kidney, where its function remains unclear. In vitro data suggested that PCSK9 could impair the trafficking of the epithelial Na channel (ENaC). Here, we aimed at determining the consequences of PCSK9-deficiency on blood pressure...

journal_title：Atherosclerosis

authors： Berger JM,Vaillant N,Le May C,Calderon C,Brégeon J,Prieur X,Hadchouel J,Loirand G,Cariou B

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine with chemokine-like functions that plays a role in several inflammatory diseases including atherosclerosis. We recently demonstrated that in addition to macrophages and endothelial cells, platelets are a source of MIF. However, the funct...

journal_title：Atherosclerosis

authors： Wirtz TH,Tillmann S,Strüßmann T,Kraemer S,Heemskerk JW,Grottke O,Gawaz M,von Hundelshausen P,Bernhagen J

更新日期：2015-03-01 00:00:00

abstract：:Atherosclerosis causing cardiovascular disease is the most common cause of death in the developed world. Early precursors of vascular changes - subclinical atherosclerosis - warrant special attention as this process can be stabilized or even reversed if treated in time. Sonographic Intima Media Thickness measurement o...

journal_title：Atherosclerosis

authors： Dalla Pozza R,Ehringer-Schetitska D,Fritsch P,Jokinen E,Petropoulos A,Oberhoffer R,Association for European Paediatric Cardiology Working Group Cardiovascular Prevention.

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Observations in the past have hypothesized an association between body iron status and coronary heart disease (CHD). Epidemiological studies to date have however been inconclusive without the existence of strongly positive or strongly negative associations between iron status and coronary heart disease. OBJ...

journal_title：Atherosclerosis

authors： Das De S,Krishna S,Jethwa A

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:Interleukin (IL)-6 is a key modulator of the acute phase response (APR), and while both are implicated in atherosclerosis, the pathological role of specific IL-6 signalling cascades is ill-defined. Since IL-6 employs the cytokine receptor gp130 to primarily activate the STAT3 pathway, here we evaluate whether...

journal_title：Atherosclerosis

authors： Jones GW,McLeod L,Kennedy CL,Bozinovski S,Najdovska M,Jenkins BJ

更新日期：2015-02-01 00:00:00

abstract：:HDL-increasing drugs such as fenofibrate and niacin have failed to decrease the cardiovascular risk in patients with type 2 diabetes. Drug-mediated quantitative and qualitative HDL modifications could be involved in these negative results. To evaluate the quantitative and qualitative effects of niacin and fenofibrate ...

journal_title：Atherosclerosis

authors： Masana L,Cabré A,Heras M,Amigó N,Correig X,Martínez-Hervás S,Real JT,Ascaso JF,Quesada H,Julve J,Palomer X,Vázquez-Carrera M,Girona J,Plana N,Blanco-Vaca F

更新日期：2015-02-01 00:00:00

abstract：:Recent work identified a high prevalence of modifiable risk factors for cardiovascular disease (CVD) among urban black South Africans. The aim was to track the progression of CVD risk factors in a multi-ethnic sample of South Africans. Participants were 173 black (aged 47.5 ± 7.8 yrs) and 186 white teachers (aged 49.6...

journal_title：Atherosclerosis

authors： Hamer M,von Känel R,Reimann M,Malan NT,Schutte AE,Huisman HW,Malan L

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:This study sought to determine the correlation between baseline cardiac medications and cardiovascular outcomes in patients with obstructive coronary artery disease (CAD) diagnosed by coronary computed tomographic angiography (CCTA). METHODS:1637 patients (mean age 64.8 ± 10.2 years, 69.6% male) with obstruc...

journal_title：Atherosclerosis

authors： Schulman-Marcus J,Hartaigh BÓ,Giambrone AE,Gransar H,Valenti V,Berman DS,Budoff MJ,Achenbach S,Al-Mallah M,Andreini D,Cademartiri F,Callister TQ,Chang HJ,Chinnaiyan K,Chow BJ,Cury R,Delago A,Hadamitzky M,Hausleiter J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that computed tomography coronary angiography (CTA) in patients with suspected coronary artery disease (CAD) predicts short term adverse events. However, there is no current data on whether identifying atherosclerosis on CTA impacts outcomes. We performed a case-control study to a...

journal_title：Atherosclerosis

authors： Budoff MJ,Liu S,Chow D,Flores F,Hsieh B,Gebow D,DeFrance T,Ahmadi N

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:Pyrophosphate (PPi) is a potent inhibitor of ectopic mineralization but its role during aortic valve calcification is not known. METHODS:Anti-calcific effect of PPi was investigated by using an in vitro model of serum-driven calcification of collagen sponges and decellularized porcine aortic valve leaflets....

journal_title：Atherosclerosis

authors： Rattazzi M,Bertacco E,Iop L,D'Andrea S,Puato M,Buso G,Causin V,Gerosa G,Faggin E,Pauletto P

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:To assess whether plasma IGFBP-2 is independently associated with components of the lipoprotein-lipid profile and to suggest a cutoff value that could identify subjects with the features of the metabolic syndrome. METHODS:In this cross-sectional study, 379 Caucasian men from the general population and coveri...

journal_title：Atherosclerosis

authors： Carter S,Li Z,Lemieux I,Alméras N,Tremblay A,Bergeron J,Poirier P,Deshaies Y,Després JP,Picard F

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Serum concentrations of high-sensitivity cardiac troponin T (hs-cTnT) are elevated in various diseases. The role of this marker in peripheral arterial disease (PAD) has not been fully investigated. METHODS:Hs-cTnT was measured in the CAVASIC Study, a male cohort of 235 patients diagnosed with intermittent c...

journal_title：Atherosclerosis

authors： Pohlhammer J,Kronenberg F,Rantner B,Stadler M,Peric S,Hammerer-Lercher A,Klein-Weigel P,Fraedrich G,Kollerits B

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:Recent data suggests that cholesteryl ester transfer protein (CETP) activity may interact with acute stress conditions via inflammatory-oxidative response and thrombogenesis. We investigated this assumption in patients with ST-elevation myocardial infarction (STEMI). METHODS:Consecutive patients with STEMI (...

journal_title：Atherosclerosis

authors： Carvalho LS,Virginio VW,Panzoldo NB,Figueiredo VN,Santos SN,Modolo RG,Andrade JM,Quinaglia E Silva JC,Nadruz-Junior W,de Faria EC,Sposito AC,Brasilia Heart Study Group.

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:The objective of this article is to review the current literature on Wnt5a and its signaling mechanism, along with its role in atherosclerosis. In addition, the significance of Wnt5a as a diagnostic marker and a potential therapeutic target is reviewed. Wnt5a, a secreted glycoprotein, belongs to a family of h...

journal_title：Atherosclerosis

authors： Bhatt PM,Malgor R

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:Being the earliest step on the way to atherosclerosis, endothelial dysfunction is particularly escalated in diabetes. This study aimed at assessing endothelial dysfunction and blood pressure disturbances in young patients with type 1 diabetes mellitus (T1DM) and defining their interrelations. METHODS:The stu...

journal_title：Atherosclerosis

authors： Machnica L,Deja G,Polanska J,Czupryniak L,Szymanska-Garbacz E,Loba J,Jarosz-Chobot P

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:The utility of lipoprotein particle profiles measured by nuclear magnetic resonance (NMR) spectroscopy beyond standard serum lipids remains inconclusive. Furthermore, few studies have compared NMR measurements with standard lipids in association with coronary artery calcification (CAC) in Japanese, where the ...

journal_title：Atherosclerosis

authors： Hisamatsu T,Fujiyoshi A,Miura K,Ohkubo T,Kadota A,Kadowaki S,Kadowaki T,Yamamoto T,Miyagawa N,Zaid M,Torii S,Takashima N,Murakami Y,Okamura T,Horie M,Ueshima H,SESSA Research Group.

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:Epidemiological, biological and clinical links between periodontal and cardiovascular diseases are now well established. Several human studies have detected bacterial DNA corresponding to periodontal pathogens in cardiovascular samples. Intraplaque hemorrhage has been associated with a higher risk of atherosc...

journal_title：Atherosclerosis

authors： Rangé H,Labreuche J,Louedec L,Rondeau P,Planesse C,Sebbag U,Bourdon E,Michel JB,Bouchard P,Meilhac O

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Anemia has been shown to be a risk factor for coronary artery disease and mortality. The involvement of body iron stores in the development of CAD remains controversial. So far, studies that examined hemoglobin and parameters of iron metabolism simultaneously do not exist. METHODS AND RESULTS:Hemoglobin and...

journal_title：Atherosclerosis

authors： Grammer TB,Kleber ME,Silbernagel G,Pilz S,Scharnagl H,Tomaschitz A,König W,März W

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:To investigate the hypothesis that COMP can influence the morphology, stability and size of murine atherosclerotic lesions. METHODS:ApoE- and ApoE/COMP-knockout mice were fed a high-fat diet to develop atherosclerotic plaques at lesion sites of three different types; inflammatory and fibrous plaques induced ...

journal_title：Atherosclerosis

authors： Bond AR,Hultgårdh-Nilsson A,Knutsson A,Jackson CL,Rauch U

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:Experimental evidence indicates that circulating insulin-like growth factor-1 (IGF-1) counteracts vascular aging and atherosclerosis, for which increased carotid artery intima-media thickness (IMT) is a marker. Yet, IGF-1 concentrations have been inconsistently associated with carotid IMT in epidemiological s...

journal_title：Atherosclerosis

authors： Ameri P,Canepa M,Fabbi P,Leoncini G,Milaneschi Y,Mussap M,AlGhatrif M,Balbi M,Viazzi F,Murialdo G,Pontremoli R,Brunelli C,Ferrucci L

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Eosinophils have been involved in a wide spectrum of pro-inflammatory and pro-thrombotic conditions, with the development of cardiovascular complications in a significant proportion of hypereosinophilic patients. However, no study has so far evaluated the impact of eosinophils levels on periprocedural myocar...

journal_title：Atherosclerosis

authors： Verdoia M,Schaffer A,Barbieri L,Sinigaglia F,Marino P,Suryapranata H,De Luca G,Novara Atherosclerosis Study Group (NAS).

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Microvascular mechanisms are increasingly recognized as being involved in a significant proportion of coronary artery disease (CAD) cases, but their exact contribution or role is unclear. We aimed to define the association between retinal microvascular signs and both CAD extent and severity. METHODS:1120 par...

journal_title：Atherosclerosis

authors： Gopinath B,Chiha J,Plant AJ,Thiagalingam A,Burlutsky G,Kovoor P,Liew G,Mitchell P

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein A1 (ApoA1) and apolipoprotein E (ApoE) mimetic peptides have attracted attention due to their ability to reduce atherosclerosis and exhibit antioxidant, anti-inflammatory, and hypolipidemic properties. In this study, we tested whether three distinct and unrelated cationic peptides would inhibit...

journal_title：Atherosclerosis

authors： Aluganti Narasimhulu C,Selvarajan K,Brown M,Parthasarathy S

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:DJ-1-a multifunctional protein responding to oxidative stress-is a possible regulator of the inflammatory response that plays an important role in atherosclerosis. Stromal cell-derived factor (SDF)-1 and its receptor, chemokine receptor type 4 (CXCR4), have been implicated in the recruitment of inflammatory c...

journal_title：Atherosclerosis

authors： Jung SH,Won KJ,Lee KP,Lee DH,Yu S,Lee DY,Seo EH,Kang H,Park ES,Kim HJ,Lee SH,Kim B

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:Atherosclerosis is a multi-step process, where lipids, inflammatory and hemostatic mediators orchestrate plaque formation and progression, which subsequently may lead to myocardial infarction and ischemic stroke. Familial hypercholesterolemia (FH) is associated with increased risk of premature atherosclerosis...

journal_title：Atherosclerosis

authors： Narverud I,Retterstøl K,Iversen PO,Halvorsen B,Ueland T,Ulven SM,Ose L,Aukrust P,Veierød MB,Holven KB

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:Although obesity is a risk factor for cardiovascular disease and mortality, several studies have reported that patients with obesity who have suffered acute myocardial infarction or have undergone percutaneous coronary intervention (PCI) have better clinical outcomes than their normal weight counterparts. We ...

journal_title：Atherosclerosis

authors： Sohn GH,Kim EK,Hahn JY,Song YB,Yang JH,Chang SA,Lee SC,Choe YH,Choi SH,Choi JH,Lee SH,Oh JK,Gwon HC

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To clarify the potential mechanisms by which oxidized low-density lipoprotein (oxLDL) could contribute to the progression of aortic valve stenosis (AVS). METHODS:We investigated a total of 46 stenotic and 20 control human aortic valves. The mRNA expression levels of scavenger receptor class A type 1 (SR-A1),...

journal_title：Atherosclerosis

authors： Syväranta S,Alanne-Kinnunen M,Oörni K,Oksjoki R,Kupari M,Kovanen PT,Helske-Suihko S

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:Olive oil protects against cardiovascular disease but the underlying mechanism is still unclear. We speculated that olive oil could inhibit oxidative stress, which is believed to be implicated in the atherosclerotic process. METHODS AND RESULTS:Post-prandial oxidative stress and endothelial dysfunction were ...

journal_title：Atherosclerosis

authors： Carnevale R,Pignatelli P,Nocella C,Loffredo L,Pastori D,Vicario T,Petruccioli A,Bartimoccia S,Violi F

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:CETP inhibitors block the transfer of cholesteryl ester from HDL-C to VLDL-C and LDL-C, thereby raising HDL-C and lowering LDL-C. In this study, we explored the effect of CETP inhibitors on hepatic LDL receptor (LDLR) and PCSK9 expression and further elucidated the underlying regulatory mechanism. RESULTS:W...

journal_title：Atherosclerosis

authors： Dong B,Singh AB,Fung C,Kan K,Liu J

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:The response to retention hypothesis of atherogenesis proposes that atherosclerosis is initiated via the retention of atherogenic lipoproteins by vascular proteoglycans. Co-localization studies suggest that of all the vascular proteoglycans, biglycan is the one most closely co-localized with LDL. The goal of ...

journal_title：Atherosclerosis

authors： Thompson JC,Tang T,Wilson PG,Yoder MH,Tannock LR

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:Deletion of inducible nitric oxide synthase (iNOS) in apolipoprotein E knockout mice was shown to mitigate the extent of arteriosclerosis. Oxidized low density lipoprotein (oxLDL) inhibits macrophage migration and traps foam cells, possibly through a mechanism involving oxidative stress. Here, we addressed wh...

journal_title：Atherosclerosis

authors： Huang H,Koelle P,Fendler M,Schröttle A,Czihal M,Hoffmann U,Conrad M,Kuhlencordt PJ

更新日期：2014-07-01 00:00:00